Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14039561 | 0.84 | METAP2 (0.47) | NPC1SMN1; SMN2RAB9AMETAP2NFKB1 | |
| SCHEMBL27909694 | 0.84 | RAD51 (0.42) | NPC1SMN1; SMN2RAB9AMETAP2L3MBTL1 | |
| SCHEMBL855275 | 0.82 | METAP2 (0.38) | NPC1SMN1; SMN2RAB9AMETAP2KDM4E | |
| SCHEMBL8012285 | 0.82 | TLR8 (0.39) | NPC1SMN1; SMN2RAB9AMETAP2NFKB1 | |
| SCHEMBL19405233 | 0.82 | ALDH1A1 (0.39) | NPC1SMN1; SMN2RAB9AL3MBTL1MAPK1 | |
| SCHEMBL457222 | 0.81 | SMN1; SMN2 (0.56) | NPC1SMN1; SMN2RAB9AL3MBTL1MAPK1 | |
| SCHEMBL10273880 | 0.81 | IDO1 (0.45) | NPC1SMN1; SMN2RAB9AMETAP2MAPT | |
| SCHEMBL27834569 | 0.81 | HRH3 (0.45) | NPC1SMN1; SMN2RAB9AMETAP2L3MBTL1 | |
| SCHEMBL948854 | 0.80 | GSK3B (0.44) | NPC1SMN1; SMN2RAB9AMAPK1LMNA | |
| SCHEMBL8010665 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104277004-B | Prepare method and its intermediate of pyridazinone compound | 住友化学株式会社 | 2016-08-24 | — | — | CN | disclosed |
| CN-104326952-B | Prepare method and its intermediate of pyridazinone compound | 住友化学株式会社 | 2016-08-24 | — | — | CN | disclosed |