Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457222 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2ADORA3ADORA2AADORA1DDAH1 | |
| SCHEMBL27909694 | 0.80 | RAD51 (0.42) | SMN1; SMN2ADORA3ADORA1 | |
| SCHEMBL14039561 | 0.80 | METAP2 (0.47) | SMN1; SMN2 | |
| SCHEMBL948854 | 0.80 | GSK3B (0.44) | SMN1; SMN2 | |
| SCHEMBL19405233 | 0.79 | ALDH1A1 (0.39) | SMN1; SMN2ADORA3ADORA2AADORA1 | |
| SCHEMBL8012285 | 0.79 | TLR8 (0.39) | SMN1; SMN2ADORA3ADORA2AADORA1 | |
| SCHEMBL28079633 | 0.79 | NPC1 (0.42) | SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL4415849 | 0.76 | GSK3B (0.33) | — | |
| SCHEMBL17599659 | 0.75 | HEXA (0.42) | ADORA3 | |
| SCHEMBL11208038 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2ADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | claimed |
| WO-1999051590-A1 | SUBSTITUTED INDOLINONES AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-14 | — | — | WO | claimed |
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |
| WO-1999051590-A1 | SUBSTITUTED INDOLINONES AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-14 | — | — | WO | disclosed |