Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.30 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6754743 | 1.00 | ALDH1A1 (0.43) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL7102435 | 1.00 | ALDH1A1 (0.43) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL39073 | 1.00 | ALDH1A1 (0.43) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20394112 | 1.00 | ALDH1A1 (0.43) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL28720004 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL2549366 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20338075 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL20271528 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL50630 | 0.94 | ALDH1A1 (0.48) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL15225288 | 0.93 | ALDH1A1 (0.47) | ALDH1A1PDE4ALMNAUSP2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114867348-A | Hypoxic blood storage and pathogen inactivation methods | 希玛奈克斯特股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-111655696-A | Compositions and methods for pathogen inactivation of platelets | 塞鲁斯公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-105998067-A | Process for preparing wound repair agent composition, tube and device | 安托万·图瑞兹 | 2016-10-12 | — | — | CN | disclosed |
| CN-103079577-B | Process for preparing wound repair agent composition, tube and device | 安托万·图瑞兹 | 2016-08-03 | — | — | CN | disclosed |