Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 8/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 5/20 | 0.53 |
| ▸ | JAK2 | O60674 | 6/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 2/20 | 0.49 |
| ▸ | MELK | Q14680 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28080559 | 0.86 | JAK3 (0.74) | JAK3JAK1JAK2ROCK2CYP3A4 | |
| SCHEMBL30009846 | 0.81 | CIT (0.65) | CITJAK1 | |
| SCHEMBL28871098 | 0.81 | CIT (0.63) | CITJAK3IKBKBCHUKJAK1 | |
| SCHEMBL30009442 | 0.77 | CIT (0.62) | CITJAK3IKBKBCHUKJAK1 | |
| SCHEMBL30009111 | 0.77 | ROCK2 (0.60) | CITJAK3IKBKBCHUKJAK1 | |
| SCHEMBL28345572 | 0.77 | JAK3 (0.74) | CITJAK3IKBKBCHUKJAK1 | |
| SCHEMBL27387789 | 0.76 | BTK (0.65) | CITJAK3IKBKBCHUKJAK1 | |
| SCHEMBL29291567 | 0.76 | CIT (0.57) | CITJAK3IKBKBCHUKJAK1 | |
| SCHEMBL101362 | 0.74 | JAK2 (0.53) | CITJAK3IKBKBJAK1JAK2 | |
| SCHEMBL30009301 | 0.74 | JAK1 (0.59) | CITJAK3IKBKBCHUKJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105712998-B | Azaindole derivatives, preparation method and medical application thereof | 上海润诺生物科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| CN-105712998-A | Azaindole derivatives, preparation method and applications thereof in medicine | 上海润诺生物科技有限公司 | 2016-06-29 | — | — | CN | disclosed |