Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20425054 | 0.84 | ACHE (0.60) | ACHEGBA1PANK3KDM4EPTPN11 | |
| SCHEMBL28059125 | 0.79 | ACHE (0.46) | MAPK8CDC7ACHEGBA1POLB | |
| SCHEMBL21715629 | 0.77 | ACHE (0.47) | MAPK8CDC7ACHEGBA1 | |
| SCHEMBL15599258 | 0.76 | ACHE (0.46) | MAPK8CDC7ACHEGBA1POLB | |
| SCHEMBL28070878 | 0.76 | MAPK8 (0.52) | MAPK8CDC7ACHEALDH1A1GBA1 | |
| SCHEMBL6502025 | 0.75 | CTSB (0.45) | ALDH1A1KDM4ETDP1POLB | |
| SCHEMBL28087268 | 0.74 | MAPK8 (0.54) | MAPK8CDC7ACHEALDH1A1GBA1 | |
| SCHEMBL27905441 | 0.74 | L3MBTL1 (0.35) | ALDH1A1KDM4ETDP1POLB | |
| SCHEMBL1992408 | 0.74 | ACHE (0.48) | ACHEPANK3KDM4EAOC3 | |
| SCHEMBL31421576 | 0.73 | ACHE (0.43) | ACHEAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814049-B | Fused tricyclic imdazole derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-105814049-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |