Sugi Predict

Sugi Predict / Compounds / SCHEMBL15599258

SCHEMBL15599258

SCHEMBL15599258

CCc1ccnc(N2CCCCC2)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 3/20 0.46
▸ SORD Q00796 1/20 0.44
▸ CCNT1 O60563 2/20 0.41
▸ CCNA2 P20248 2/20 0.41
▸ CDK2 P24941 2/20 0.41
▸ CDK9 P50750 2/20 0.41
▸ HTR1A P08908 1/20 0.41
▸ DRD2 P14416 1/20 0.41
▸ HTR2A P28223 1/20 0.41
▸ HTR7 P34969 1/20 0.41
▸ HTR6 P50406 1/20 0.41
▸ MAPK8 P45983 1/20 0.40
▸ CDC7 O00311 1/20 0.40
▸ DYRK1A Q13627 1/20 0.40
▸ CHRNA7 P36544 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ GBA1 P04062 1/20 0.39
▸ CA12 O43570 1/20 0.38
▸ CA1 P00915 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21715629 0.98 ACHE (0.47) ACHESORDCCNT1CCNA2CDK2
SCHEMBL30230267 0.85 HTR1A (0.56) ACHESORDCCNT1CCNA2CDK2
SCHEMBL17827961 0.85 PIK3CA (0.51) ACHESORDCCNT1CCNA2CDK2
SCHEMBL28059125 0.83 ACHE (0.46) ACHESORDCCNT1CCNA2CDK2
SCHEMBL24920520 0.82 MAPT (0.46) ACHECCNT1CCNA2CDK2CDK9
SCHEMBL30338356 0.82 SORD (0.41) ACHESORDHTR1ADRD2HTR2A
SCHEMBL25236518 0.82 SORD (0.41) ACHESORDHTR1ADRD2HTR2A
SCHEMBL24921040 0.80 AOC3 (0.44) ACHECCNT1CCNA2CDK2CDK9
SCHEMBL20804677 0.79 ACHE (0.56) ACHESORDGBA1
SCHEMBL31421576 0.77 ACHE (0.43) ACHESORDCCNT1CCNA2CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12037328-B2 Compounds containing benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of G protein-coupled receptor 119 PRAMANA PHARMACEUTICALS INC. (CA) 2024-07-16 — — US disclosed
US-11358956-B2 Compounds containing polysubstituted benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of G protein-coupled receptor 119 PRAMANA PHARMACEUTICALS INC. (CA) 2022-06-14 — — US disclosed
CN-105814043-B Triazolopyridine derivatives as TNF active regulator UCB生物制药私人有限公司 2019-05-17 — — CN disclosed
CN-105814049-B Fused tricyclic imdazole derivatives as TNF active regulator UCB生物制药私人有限公司 2019-03-12 — — CN disclosed
CN-105814041-B Benzotriazole derivatives as TNF active regulator UCB生物制药私人有限公司 2018-12-18 — — CN disclosed
CN-105814058-B Triazolo-pyridazine derivatives as TNF active regulator UCB生物制药私人有限公司 2018-11-23 — — CN disclosed
CN-105814065-B Imidazothiazole derivative as TNF active regulator UCB生物制药私人有限公司 2018-11-23 — — CN disclosed
CN-105814047-B Fused tricyclic imdazole derivatives as TNF active regulators UCB生物制药私人有限公司 2018-10-19 — — CN disclosed
CN-105814051-B Tetrahydroimidazopyridine derivatives as modulators of TNF activity UCB生物制药私人有限公司 2018-09-25 — — CN disclosed
CN-105814025-B Tetrahydrobenzimidazderivative derivative as TNF active regulators UCB生物制药私人有限公司 2018-09-04 — — CN disclosed
CN-105814048-A Fused tricyclic imidazole derivatives as modulators of TNF activity UCB生物制药私人有限公司 2016-07-27 — — CN disclosed
CN-105814060-A Imidazotriazine derivatives as modulators of TNF activity UCB生物制药私人有限公司 2016-07-27 — — CN disclosed
CN-105814059-A Imidazopyrimidine derivatives as modulators of TNF activity UCB生物制药私人有限公司 2016-07-27 — — CN disclosed
CN-105814056-A Purine derivatives as modulators of TNF activity UCB生物制药私人有限公司 2016-07-27 — — CN disclosed
CN-105814061-A Imidazopyridazine derivatives as modulators of TNF activity UCB生物制药私人有限公司 2016-07-27 — — CN disclosed
CN-105814046-A Imidazopyridine derivatives as modulators of TNF activity UCB生物制药私人有限公司 2016-07-27 — — CN disclosed
CN-105814045-A Imidazopyridine derivatives as modulators of TNF activity UCB生物制药私人有限公司 2016-07-27 — — CN disclosed
WO-2014153037-A1 SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2014-09-25 — — WO disclosed
WO-2014144545-A2 SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2014-09-18 — — WO disclosed
WO-2014008458-A2 N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2014-01-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11358956-B2 Compounds containing polysubstituted benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of G protein-coupled receptor 119 GPR119, GPR27, GCGR ACHE 4834/4885SORD 2554/4885CCNT1 2872/4885
US-12037328-B2 Compounds containing benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of G protein-coupled receptor 119 GPR119, GPR3, GPR39 ACHE 4690/4885SORD 2603/4885CCNT1 3918/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.