SCHEMBL28084356

SCHEMBL28084356

N#Cc1cc(-c2ccccc2)c2c(c1)-c1c(C#N)cccc1C2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.44
METAP2 P50579 1/20 0.39
MET P08581 1/20 0.38
TRPA1 O75762 2/20 0.37
SQOR Q9Y6N5 1/20 0.36
DRD2 P14416 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
KDM4E B2RXH2 1/20 0.35
GALR3 O60755 1/20 0.35
ALDH1A1 P00352 1/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.35
ESR2 Q92731 1/20 0.34
PRCP P42785 1/20 0.34
GABRG2 P18507 1/20 0.34
GABRB3 P28472 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17954602 0.76 TRPA1 (0.42) KCNH2TRPA1DRD2LAP3MAOA
SCHEMBL24521214 0.75 KCNH2 (0.43) KCNH2TRPA1SQORCYP1A2CYP2C9
SCHEMBL24521132 0.73 KCNH2 (0.42) KCNH2SQORNPSR1KDM4EALDH1A1
SCHEMBL17954603 0.73 DRD2 (0.46) KCNH2TRPA1DRD2KDM4EALDH1A1
SCHEMBL1036253 0.73 DRD2 (0.46) KCNH2TRPA1SQORDRD2ESR2
SCHEMBL11677346 0.73 TRPA1 (0.42) KCNH2TRPA1DRD2MAOAMAOB
SCHEMBL24521134 0.72 KCNH2 (0.41) KCNH2TRPA1SQORCYP1A2CYP2C9
SCHEMBL28832495 0.72 ADORA2A (0.41) DRD2PRCPADORA2AADORA1
SCHEMBL20740870 0.70 METAP2 (0.51) METAP2ALDH1A1HPGDPTGDR2GABRG2
SCHEMBL819087 0.70 KCNH2 (0.46) KCNH2TRPA1DRD2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105906546-B Fluorine derivative for organic electroluminescence device 默克专利有限公司 2019-02-22 CN disclosed
CN-105906546-A FLUORINE DERIVATIVES FOR ORGANIC ELECTROLUMINESCENCE DEVICES 默克专利有限公司 2016-08-31 CN disclosed