Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.50 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.50 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.50 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21060383 | 0.80 | KMO (0.44) | GRIN2DGRIN3BGRIK1GRIA1GRIA2 | |
| SCHEMBL10323102 | 0.78 | GLP1R (0.49) | ALDH1A1HSD17B10KDM4EHPGDMAPT | |
| SCHEMBL5823297 | 0.78 | ALDH1A1 (0.41) | GRIN2DGRIN3BGRIK1GRIA1GRIA2 | |
| SCHEMBL18984392 | 0.75 | GRIN2D (0.41) | GRIN2DGRIN3BGRIK1GRIA1GRIA2 | |
| SCHEMBL8802100 | 0.72 | DYRK1A (0.47) | GRIN2DGRIN3BGRIK1GRIA1GRIA2 | |
| SCHEMBL30556744 | 0.72 | DYRK1A (0.47) | GRIN2DGRIN3BGRIK1GRIA1GRIA2 | |
| SCHEMBL19701194 | 0.72 | CSNK2A1 (0.43) | MAOBALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL2777042 | 0.70 | ALDH1A1 (0.59) | GRIN2DGRIN3BGRIK1GRIA1GRIA2 | |
| SCHEMBL24984444 | 0.69 | PTGS2 (0.42) | MAOBENPP2KMODYRK1ACDK9 | |
| SCHEMBL4513173 | 0.69 | PTPRC (0.56) | MAOBALDH1A1HSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106117193-A | New Hete rocyclic derivatives and the application in nervous system disease is treated thereof | 诺华股份有限公司 | 2016-11-16 | — | — | CN | disclosed |
| CN-103403001-B | Heterocyclic derivatives and their use in the treatment of neurological disorders | 诺瓦提斯公司 | 2016-08-17 | — | — | CN | disclosed |