Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Iproclozide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.62 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iproclozide SCHEMBL49744 | 0.86 | KMT2A (0.56) | HPGDLMNAKDM4ENPSR1KMT2A | |
| Nialamide SCHEMBL28877047 | 0.84 | KMT2A (0.52) | MAOAMAOBPTGS2HPGDLMNA | |
| Iproniazid SCHEMBL4153 | 0.79 | MAOA (1.00) | MAOAMAOBPTGS2HPGDLMNA | |
| Iproniazid SCHEMBL158555 | 0.77 | HPGD (1.00) | MAOAMAOBPTGS2HPGDLMNA | |
| Iproniazid SCHEMBL3597361 | 0.77 | MAOA (0.96) | MAOAMAOBPTGS2HPGDLMNA | |
| Iproniazid SCHEMBL3001881 | 0.77 | MAOA (0.96) | MAOAMAOBPTGS2HPGDLMNA | |
| SCHEMBL15486113 | 0.76 | PTGS2 (0.62) | MAOAMAOBPTGS2HPGDLMNA | |
| SCHEMBL31407256 | 0.73 | LMNA (0.53) | LMNAKDM4ENPSR1KMT2AMEN1 | |
| SCHEMBL8248742 | 0.73 | SMN1; SMN2 (0.64) | HPGDLMNAKDM4ENPSR1KMT2A | |
| Iproniazid SCHEMBL15200763 | 0.73 | HPGD (1.00) | MAOAMAOBPTGS2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |