Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.82 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.82 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.82 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | ABL1 | P00519 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.67 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.56 |
| ▸ | TUBB | P07437 | 3/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flubendazole SCHEMBL20815724 | 0.92 | KDR (0.69) | KDRMAPK1ADORA3PTGS1RXFP1 | |
| Flubendazole SCHEMBL6232065 | 0.91 | KDR (1.00) | KDRMAPK1ADORA3PTGS1RXFP1 | |
| Flubendazole SCHEMBL31704404 | 0.91 | KDR (1.00) | KDRMAPK1ADORA3PTGS1RXFP1 | |
| Cyclobendazole SCHEMBL1649791 | 0.91 | LMNA (0.65) | KDRMAPK1ADORA3PTGS1RXFP1 | |
| Cyclobendazole SCHEMBL31544741 | 0.91 | LMNA (0.65) | KDRMAPK1ADORA3PTGS1RXFP1 | |
| Cyclobendazole SCHEMBL159525 | 0.82 | LMNA (0.53) | KDRMAPK1ADORA3PTGS1RXFP1 | |
| Flubendazole SCHEMBL29409278 | 0.82 | KDR (0.82) | KDRMAPK1ADORA3PTGS1RXFP1 | |
| Flubendazole SCHEMBL167185 | 0.82 | KDR (0.82) | KDRMAPK1ADORA3PTGS1RXFP1 | |
| Flubendazole SCHEMBL22321861 | 0.81 | KDR (0.80) | KDRMAPK1ADORA3PTGS1RXFP1 | |
| Mebendazole SCHEMBL29390263 | 0.81 | ABL1 (1.00) | KDRMAPK1ADORA3PTGS1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |