Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13165656 | 0.92 | BDKRB1 (0.40) | BTKBDKRB1POLBP2RX7CCR5 | |
| SCHEMBL2810276 | 0.88 | P2RX7 (0.38) | BDKRB1POLBP2RX7EPHX2ALDH1A1 | |
| SCHEMBL2808204 | 0.88 | P2RX7 (0.39) | BDKRB1POLBP2RX7EPHX2ALDH1A1 | |
| SCHEMBL2812285 | 0.88 | POLB (0.36) | BDKRB1POLBP2RX7EPHX2ALDH1A1 | |
| SCHEMBL2787971 | 0.87 | CCR5 (0.38) | BTKPOLBP2RX7CCR5NPSR1 | |
| SCHEMBL2787448 | 0.86 | L3MBTL1 (0.36) | BDKRB1POLBP2RX7EPHX2ALDH1A1 | |
| SCHEMBL2810838 | 0.85 | BTK (0.35) | BTKPOLBP2RX7EPHX2ALDH1A1 | |
| SCHEMBL2813227 | 0.85 | POLB (0.35) | BDKRB1POLBP2RX7EPHX2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2787349 | 0.85 | POLB (0.35) | BDKRB1POLBP2RX7EPHX2ALDH1A1 | |
| SCHEMBL2788425 | 0.84 | EPHX2 (0.41) | BDKRB1POLBP2RX7EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097374-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |