SCHEMBL28087228

SCHEMBL28087228

CNn1cc(C(=O)O)c(=O)c2ccccc21

nearest known ligand 0.55

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.55
KDM4E B2RXH2 2/20 0.51
CHRM1 P11229 4/20 0.49
CNR2 P34972 1/20 0.45
TP53 P04637 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4768322 0.82 LMNA (0.52) LMNAKDM4ECHRM1
SCHEMBL9168466 0.80 KDM4E (0.46) LMNAKDM4E
SCHEMBL398161 0.79 POLB (0.61) LMNAKDM4E
SCHEMBL30421484 0.79 POLB (0.61) LMNAKDM4E
SCHEMBL6313804 0.78 LMNA (0.62) LMNAKDM4ECHRM1
SCHEMBL28735738 0.77 PDE4A (0.49) LMNAKDM4EL3MBTL1
SCHEMBL8129957 0.76 ALDH1A1 (0.44) LMNAKDM4E
SCHEMBL7545236 0.76 LMNA (0.59) LMNAKDM4ECHRM1TP53
SCHEMBL28274592 0.76 LMNA (0.59) LMNAKDM4ECHRM1CNR2
SCHEMBL30747701 0.76 LMNA (0.59) LMNAKDM4ECHRM1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105130892-B The preparation of Marbofloxacin key intermediate 海门慧聚药业有限公司 2016-08-17 CN disclosed