Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.32 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 2/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28139174 | 0.76 | CA12 (0.36) | KDM4EKMT2AHIF1A | |
| SCHEMBL28259334 | 0.74 | ALDH1A1 (0.44) | KDM4EKMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6208150 | 0.74 | ESR2 (0.41) | ESR2ESR1CYP3A4CYP2C9MRGPRX4 | |
| SCHEMBL27936928 | 0.74 | ESR1 (0.42) | KDM4ESMN1; SMN2ESR2ESR1 | |
| SCHEMBL28088993 | 0.74 | ACACA (0.41) | CHRNA7 | |
| SCHEMBL27767221 | 0.73 | GBA1 (0.38) | MBOAT4KDM4EKMT2A | |
| SCHEMBL7282981 | 0.73 | SYK (0.40) | KDM4EKMT2ACYP3A4RXRAGRIN1 | |
| SCHEMBL28089027 | 0.73 | GRM2 (0.37) | MBOAT4KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL22717430 | 0.72 | MBOAT4 (0.42) | MBOAT4KDM4EGLAHTTKMT2A | |
| SCHEMBL1758550 | 0.72 | KDM4E (0.42) | MBOAT4KDM4EGLAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106349156-B | It can be used as the pyridine -2- amides of CB2 agonist | 霍夫曼-拉罗奇有限公司 | 2018-12-11 | — | — | CN | disclosed |
| CN-106349156-A | Pyridine-2-amides capable of being used as CB2 agonist | 霍夫曼-拉罗奇有限公司 | 2017-01-25 | — | — | CN | disclosed |
| CN-103608332-B | Pyridine-2-amides useful as CB2 agonists | 霍夫曼-拉罗奇有限公司 | 2016-09-28 | — | — | CN | disclosed |