Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5474506 | 0.88 | ALDH1A1 (0.65) | ALDH1A1KDM4EMAPTALOX15SMN1; SMN2 | |
| Citric Acid SCHEMBL3851025 | 0.88 | ALDH1A1 (0.65) | ALDH1A1KDM4EMAPTALOX15SMN1; SMN2 | |
| Citric Acid SCHEMBL29168513 | 0.86 | ALDH1A1 (0.62) | ALDH1A1KDM4EMAPTALOX15SMN1; SMN2 | |
| Citric Acid SCHEMBL3388434 | 0.86 | ALDH1A1 (0.68) | ALDH1A1CA4KDM4EMAPTALOX15 | |
| Citric Acid SCHEMBL29280333 | 0.86 | ALDH1A1 (0.68) | ALDH1A1CA4KDM4EMAPTALOX15 | |
| Citric Acid SCHEMBL25331242 | 0.84 | ALDH1A1 (0.65) | ALDH1A1CA4KDM4EMAPTALOX15 | |
| Citric Acid SCHEMBL11747873 | 0.84 | ALDH1A1 (0.65) | ALDH1A1CA4KDM4EMAPTALOX15 | |
| Citric Acid SCHEMBL31171639 | 0.84 | ALDH1A1 (0.65) | ALDH1A1CA4KDM4EMAPTALOX15 | |
| Citric Acid SCHEMBL28939048 | 0.84 | ALDH1A1 (0.65) | ALDH1A1CA4KDM4EMAPTALOX15 | |
| Citric Acid SCHEMBL10477646 | 0.84 | ALDH1A1 (0.71) | ALDH1A1CA4KDM4EMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105820188-A | Medicinal preparation containing tenofovir disoproxil fumarate (vitamin E), and use thereof | 刘天军 | 2016-08-03 | — | — | CN | disclosed |