Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Mandelic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | NAAA | Q02083 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mandelic Acid SCHEMBL2770258 | 0.93 | LMNA (0.75) | LMNAMAPK1SRCNAAAHPGD | |
| Mandelic Acid SCHEMBL2774964 | 0.91 | LMNA (0.78) | LMNAMAPK1SRCNAAAHPGD | |
| Mandelic Acid SCHEMBL4847480 | 0.85 | LMNA (0.82) | LMNAMAPK1SRCNAAAHPGD | |
| Mandelic Acid SCHEMBL1737708 | 0.81 | LMNA (0.69) | LMNAMAPK1SRCNAAAHPGD | |
| Mandelic Acid SCHEMBL2689215 | 0.81 | LMNA (0.75) | LMNAMAPK1SRCNAAAHPGD | |
| Mandelic Acid SCHEMBL3456058 | 0.81 | LMNA (0.62) | LMNAMAPK1SRCNAAAHPGD | |
| Mandelic Acid SCHEMBL30249457 | 0.81 | LMNA (0.82) | LMNAMAPK1SRCNAAAHPGD | |
| Mandelic Acid SCHEMBL28154998 | 0.81 | LMNA (0.82) | LMNAMAPK1SRCNAAAHPGD | |
| Mandelic Acid SCHEMBL7279536 | 0.80 | LMNA (0.90) | LMNAMAPK1SRCNAAAHPGD | |
| Mandelic Acid SCHEMBL29777368 | 0.80 | LMNA (1.00) | LMNAMAPK1SRCHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103553966-B | The solid forms of SARM | GTX公司 | 2016-09-07 | — | — | CN | disclosed |