Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8658566 | 0.96 | TSHR (0.35) | TSHRSOS1SOS2 | |
| SCHEMBL27955879 | 0.85 | TSHR (0.30) | TSHR | |
| SCHEMBL11722966 | 0.80 | SOS1 (0.34) | TSHRSOS1SOS2 | |
| SCHEMBL319587 | 0.78 | TSHR (0.34) | TSHRSOS1SOS2 | |
| SCHEMBL27806671 | 0.77 | MEN1 (0.33) | SOS1SOS2 | |
| SCHEMBL8655459 | 0.76 | TSHR (0.33) | TSHRSOS1SOS2 | |
| SCHEMBL27827298 | 0.74 | GNAO1 (0.38) | — | |
| SCHEMBL9801465 | 0.72 | TSHR (0.36) | TSHRSOS1SOS2 | |
| SCHEMBL28137826 | 0.72 | TSHR (0.31) | TSHR | |
| SCHEMBL6838356 | 0.71 | TSHR (0.35) | TSHRSOS1SOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105848757-B | The method of capture sulfur dioxide from gas stream | 康世富技术公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-104755466-B | The preparation of dihydroxy ethyl piperazine | 陶氏环球技术有限责任公司 | 2016-08-17 | — | — | CN | disclosed |