Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 3/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28219782 | 0.85 | SRC (0.57) | SMN1; SMN2LMNATDP1KMT2AFDPS | |
| SCHEMBL27714398 | 0.82 | KMT2A (0.45) | SMN1; SMN2LMNATDP1KMT2AFDPS | |
| SCHEMBL4744280 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNATDP1KMT2AFDPS | |
| SCHEMBL18301043 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNATDP1KMT2AFDPS | |
| SCHEMBL27647649 | 0.77 | FDPS (0.45) | SMN1; SMN2LMNATDP1FDPSCHRNB2 | |
| SCHEMBL4679260 | 0.77 | FDPS (0.44) | SMN1; SMN2LMNATDP1KMT2AFDPS | |
| SCHEMBL4744278 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNATDP1KMT2ACHRNB2 | |
| SCHEMBL10932461 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNATDP1KMT2ACHRNB2 | |
| SCHEMBL27998020 | 0.76 | LMNA (0.43) | SMN1; SMN2LMNATDP1KMT2ACHRNB2 | |
| SCHEMBL27707122 | 0.76 | CYP2C19 (0.53) | SMN1; SMN2LMNAKMT2ACYP2C19FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596985-B | 17-hydroxy-17-pentafluoroethyl-estra-4, 9(10) -dien-11-aryl derivatives, method for the production thereof and use thereof for treating diseases | 拜耳知识产权有限责任公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-106046100-A | 17-hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl derivatives, methods for the production thereof and the use thereof for treating diseases | 拜耳知识产权有限责任公司 | 2016-10-26 | — | — | CN | disclosed |