Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCL2 | P13500 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397326 | 0.80 | MAOA (0.38) | CHEK2MAOADYRK1AMAPK1CYP1A2 | |
| SCHEMBL27926026 | 0.79 | TP53 (0.50) | MAPK1ALDH1A1HSD17B10TSHR | |
| SCHEMBL28039593 | 0.79 | MAOA (0.33) | CHEK2MAOADYRK1ACHEK1MAPK1 | |
| SCHEMBL589802 | 0.79 | CHRNB2 (0.49) | ALDH1A1 | |
| SCHEMBL16741209 | 0.79 | SYK (0.37) | CHEK2MAOADYRK1AMAPK1CYP1A2 | |
| SCHEMBL6301382 | 0.79 | TIPARP (0.36) | MAOADYRK1AMAPK1CYP1A2CYP2D6 | |
| SCHEMBL27688593 | 0.79 | FBP1 (0.35) | CHEK2MAOADYRK1AMAPK1CYP1A2 | |
| SCHEMBL4601269 | 0.79 | MAOA (0.35) | CHEK2MAOADYRK1ACHEK1MAPK1 | |
| SCHEMBL15474940 | 0.79 | MAPK1 (0.40) | CHEK2MAOADYRK1AMAPK1CYP1A2 | |
| SCHEMBL2021195 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110354128-A | Pyrimidine FGFR4 inhibitors | 卫材R&D管理有限公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-105899490-B | Pyrimidine FGFR4 Inhibitors | 卫材R&D管理有限公司 | 2019-07-23 | — | — | CN | disclosed |
| CN-105899490-A | Pyrimidine fgfr4 inhibitors | 卫材R&D管理有限公司 | 2016-08-24 | — | — | CN | disclosed |