Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.51 |
| ▸ | NOS1 | P29475 | 3/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 5/20 | 0.39 |
| ▸ | CPB1 | P15086 | 3/20 | 0.39 |
| ▸ | ARG1 | P05089 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12610414 | 0.93 | SLC1A3 (0.44) | GSRNOS1SLC1A3CPB2CPB1 | |
| SCHEMBL12610410 | 0.93 | SLC1A3 (0.44) | GSRNOS1SLC1A3CPB2CPB1 | |
| SCHEMBL8824879 | 0.88 | SLC1A3 (0.51) | NOS1SLC1A3GRIA1GRIA2GRIA3 | |
| SCHEMBL28559 | 0.88 | SLC1A3 (0.51) | NOS1SLC1A3GRIA1GRIA2GRIA3 | |
| SCHEMBL8824882 | 0.88 | SLC1A3 (0.51) | NOS1SLC1A3GRIA1GRIA2GRIA3 | |
| SCHEMBL4587261 | 0.88 | SLC1A3 (0.51) | NOS1SLC1A3GRIA1GRIA2GRIA3 | |
| SCHEMBL28560 | 0.88 | SLC1A3 (0.51) | NOS1SLC1A3GRIA1GRIA2GRIA3 | |
| Hydrochloric Acid SCHEMBL7049998 | 0.86 | SLC1A3 (0.50) | NOS1SLC1A3GRIA1GRIA2GRIA3 | |
| Homoserine SCHEMBL28894150 | 0.85 | NOS1 (0.45) | NOS1SLC1A3ARG1GRIA1GRIA2 | |
| SCHEMBL27203721 | 0.84 | NOS1 (0.42) | NOS1SLC1A3THRBARG1GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108430506-A | T cell receptor (TCR) binding antibodies and uses thereof | 得克萨斯州大学系统董事会 | 2018-08-21 | — | — | CN | disclosed |
| CN-106188270-A | Rhamm binding peptide | 伦敦健康科学研究中心有限公司 | 2016-12-07 | — | — | CN | disclosed |
| CN-103038248-B | RHAMM binding peptides | 伦敦健康科学研究中心有限公司 | 2016-08-10 | — | — | CN | disclosed |