Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 3/20 | 0.46 |
| ▸ | KDM5A | P29375 | 3/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NT5E | P21589 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28097403 | 0.89 | NR3C2 (0.51) | NR3C2KDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL28097404 | 0.88 | NR3C1 (0.50) | NR3C2KDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL28097416 | 0.86 | KDM5A (0.49) | NR3C2KDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL28097405 | 0.82 | MEN1 (0.50) | NR3C2ALDH1A1MAPTATMMAPK9 | |
| SCHEMBL28097406 | 0.80 | NR3C2 (0.51) | NR3C2KDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL15557300 | 0.79 | MEN1 (0.43) | NR3C2KDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL17086629 | 0.78 | MAPT (0.54) | NR3C2KDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL17086632 | 0.77 | MEN1 (0.50) | NR3C2KDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL12759885 | 0.77 | MDM2 (0.52) | NR3C2KDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL15556452 | 0.76 | KDM5A (0.52) | NR3C2KDM5AKDM4CKDM5BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104487438-B | Benzisoxazole modulators of neurogenesis | 霍夫曼-拉罗奇有限公司 | 2016-10-19 | — | — | CN | claimed |
| CN-104487438-B | Benzisoxazole modulators of neurogenesis | 霍夫曼-拉罗奇有限公司 | 2016-10-19 | — | — | CN | disclosed |