Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486087 | 0.87 | KIF11 (0.50) | HSP90AA1HSP90AB1RIPK1ROCK2KIF11 | |
| SCHEMBL28168147 | 0.85 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1RIPK1ROCK2 | |
| SCHEMBL216202 | 0.84 | RIPK1 (0.62) | HSP90AA1HSP90AB1RIPK1HSD11B1PARP14 | |
| SCHEMBL27574934 | 0.84 | RIPK1 (0.62) | HSP90AA1HSP90AB1RIPK1HSD11B1PARP14 | |
| SCHEMBL27574946 | 0.84 | RIPK1 (0.62) | HSP90AA1HSP90AB1RIPK1HSD11B1PARP14 | |
| SCHEMBL25319552 | 0.84 | SCD5 (0.47) | HSP90AA1HSP90AB1RIPK1TMEM97SIGMAR1 | |
| SCHEMBL6246105 | 0.84 | RIPK1 (0.66) | HSP90AA1HSP90AB1RIPK1TMEM97SIGMAR1 | |
| SCHEMBL27341297 | 0.84 | PRMT5 (0.49) | RIPK1ROCK2HSD11B1 | |
| SCHEMBL25322214 | 0.83 | TMEM97 (0.57) | HSP90AA1HSP90AB1RIPK1TMEM97SIGMAR1 | |
| Water SCHEMBL27700791 | 0.83 | RIPK1 (0.60) | HSP90AA1HSP90AB1RIPK1HSD11B1PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103534258-B | Tyrosine kinase inhibitor | 普林斯匹亚生物制药公司 | 2016-09-14 | — | — | CN | disclosed |