Probenazol

Probenazol

SCHEMBL28097551

C=CCOC1=NS(=O)(=O)c2ccccc21.O=C1CCc2cccc3c2N1CC3

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.44
RAB9A P51151 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.38
ADRA2A P08913 1/20 0.38
ADRA2B P18089 1/20 0.38
ADRA2C P18825 1/20 0.38
LMNA P02545 1/20 0.37
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA4 P22748 1/20 0.37
CA7 P43166 1/20 0.37
CA9 Q16790 1/20 0.37
CYP11B1 P15538 9/20 0.37
CYP11B2 P19099 9/20 0.37
CYP19A1 P11511 5/20 0.37
ALDH1A1 P00352 2/20 0.37
HTR1A P08908 1/20 0.36
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Probenazol SCHEMBL30425932 0.80 PKM (0.65) PKMRAB9AL3MBTL1LMNAALDH1A1
Probenazol SCHEMBL23516 0.80 PKM (0.65) PKMRAB9AL3MBTL1LMNAALDH1A1
Probenazol SCHEMBL8409812 0.80 PKM (0.65) PKMRAB9AL3MBTL1LMNAALDH1A1
Probenazol SCHEMBL3027350 0.73 PKM (0.56) PKMRAB9AL3MBTL1LMNACA12
Pyroquilon SCHEMBL8820252 0.69 MAP2K1 (0.55) L3MBTL1CA12CA1CA2CA4
Pyroquilon SCHEMBL29473240 0.69 MAP2K1 (0.55) L3MBTL1CA12CA1CA2CA4
Pyroquilon SCHEMBL22234 0.69 MAP2K1 (0.55) L3MBTL1CA12CA1CA2CA4
Pyroquilon SCHEMBL19409911 0.68 MAP2K1 (0.54) L3MBTL1CA12CA1CA2CA4
Pyroquilon SCHEMBL29473172 0.68 MAP2K1 (0.54) L3MBTL1CA12CA1CA2CA4
Pyroquilon SCHEMBL29473298 0.67 MAP2K1 (0.53) L3MBTL1CA12CA1CA2CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105492432-B Tetrazolinone compound and use thereof 住友化学株式会社 2019-06-14 CN disclosed
CN-105392779-B Tetrazolinone compound and use thereof 住友化学株式会社 2018-01-19 CN disclosed
CN-104884442-B Terazololine-one compound and application thereof 住友化学株式会社 2016-11-02 CN disclosed
CN-104822666-B Terazololine-one compound and application thereof 住友化学株式会社 2016-09-21 CN disclosed