Probenazol

Probenazol

SCHEMBL8409812

C=CCOC1=NS(=O)(=O)c2ccccc21.C=CCOC1=NS(=O)(=O)c2ccccc21

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.65
ALDH1A1 P00352 3/20 0.54
LMNA P02545 2/20 0.51
GAA P10253 3/20 0.49
HSD17B10 Q99714 3/20 0.49
HTT P42858 1/20 0.49
KDM4E B2RXH2 2/20 0.47
MAPT P10636 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
RAB9A P51151 1/20 0.44
THRB P10828 1/20 0.43
ALOX15 P16050 1/20 0.43
RECQL P46063 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
RHOA P61586 1/20 0.43
KCNA3 P22001 4/20 0.41
PTPRC P08575 1/20 0.41
HPGD P15428 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Probenazol SCHEMBL23516 1.00 PKM (0.65) PKMALDH1A1LMNAGAAHSD17B10
Probenazol SCHEMBL30425932 1.00 PKM (0.65) PKMALDH1A1LMNAGAAHSD17B10
Probenazol SCHEMBL3027350 0.92 PKM (0.56) PKMALDH1A1LMNAGAAHSD17B10
Probenazol SCHEMBL28877681 0.81 PKM (0.44) PKMALDH1A1LMNAGAAHSD17B10
Probenazol SCHEMBL28097551 0.80 PKM (0.44) PKMALDH1A1LMNAGAAKDM4E
Thiophanate Methyl SCHEMBL28220504 0.79 HSD17B10 (0.51) PKMALDH1A1LMNAGAAHSD17B10
SCHEMBL8437480 0.79 PKM (1.00) PKMALDH1A1LMNAGAAHSD17B10
Thiophanate Methyl SCHEMBL28115100 0.78 PKM (0.45) PKMALDH1A1LMNAGAAHSD17B10
Isoprothiolane SCHEMBL9239101 0.78 PKM (0.44) PKMALDH1A1LMNAGAAHSD17B10
SCHEMBL6910103 0.76 PKM (0.77) PKMALDH1A1LMNAGAAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5863909-A CONSISTS OF SORBITAN/FATTY ACID ESTER SURFACTANT AND OTHER SURFACTANT SELECTED FROM RESIN ACID AND ANIONIC OLIGOMER OR POLYMER TYPE QUATERNARY AMMONIUM SALTS KAO CORPORATION (JP) 1999-01-26 US disclosed