Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Probenazol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Probenazol SCHEMBL8409812 | 0.92 | PKM (0.65) | PKMALDH1A1LMNAGAAHSD17B10 | |
| Probenazol SCHEMBL30425932 | 0.92 | PKM (0.65) | PKMALDH1A1LMNAGAAHSD17B10 | |
| Probenazol SCHEMBL23516 | 0.92 | PKM (0.65) | PKMALDH1A1LMNAGAAHSD17B10 | |
| Probenazol SCHEMBL28877681 | 0.74 | PKM (0.44) | PKMALDH1A1LMNAGAAHSD17B10 | |
| Probenazol SCHEMBL28097551 | 0.73 | PKM (0.44) | PKMALDH1A1LMNAGAAKDM4E | |
| Thiophanate Methyl SCHEMBL28220504 | 0.73 | HSD17B10 (0.51) | PKMALDH1A1LMNAGAAHSD17B10 | |
| SCHEMBL8437480 | 0.72 | PKM (1.00) | PKMALDH1A1LMNAGAAHSD17B10 | |
| Thiophanate Methyl SCHEMBL28115100 | 0.72 | PKM (0.45) | PKMALDH1A1LMNAGAAHSD17B10 | |
| Isoprothiolane SCHEMBL9239101 | 0.71 | PKM (0.44) | PKMALDH1A1LMNAGAAHSD17B10 | |
| SCHEMBL6910103 | 0.70 | PKM (0.77) | PKMALDH1A1LMNAGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10555520-B2 | Pesticide composition potentiated in efficacy and method for potentiating efficacy of pesticidal active ingredients | NIPPON SODA CO., LTD. (JP) | 2020-02-11 | — | — | US | disclosed |
| US-20180146664-A1 | PESTICIDE COMPOSITION POTENTIATED IN EFFICACY AND METHOD FOR POTENTIATING EFFICACY OF PESTICIDAL ACTIVE INGREDIENTS | NIPPON SODA CO., LTD. (JP) | 2018-05-31 | — | — | US | disclosed |
| EP-2183968-B1 | PESTICIDE COMPOSITION POTENTIATED IN EFFICACY AND METHOD FOR POTENTIATING THE EFFICACY OF PESTICIDAL ACTIVE INGREDIENTS | NIPPON SODA CO (JP) | 2014-11-05 | — | — | EP | disclosed |
| US-20100204283-A1 | PESTICIDE COMPOSITION POTENTIATED IN EFFICACY AND METHOD FOR POTENTIATING EFFICACY OF PESTICIDAL ACTIVE INGREDIENTS | NIPPON SODA CO., LTD. (JP) | 2010-08-12 | — | — | US | disclosed |
| EP-2183968-A1 | PESTICIDE COMPOSITION POTENTIATED IN EFFICACY AND METHOD FOR POTENTIATING THE EFFICACY OF PESTICIDAL ACTIVE INGREDIENTS | Nippon Soda Co., Ltd. (JP) | 2010-05-12 | — | — | EP | disclosed |