Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.75 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.61 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.75 |
| ▸ | TSHR | P16473 | 5/20 | 0.75 |
| ▸ | BLM | P54132 | 4/20 | 0.75 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.75 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.75 |
| ▸ | THRB | P10828 | 2/20 | 0.75 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.75 |
| ▸ | GABRP | O00591 | 1/20 | 0.75 |
| ▸ | GABRD | O14764 | 1/20 | 0.75 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.75 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.75 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.75 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.75 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gamma-Aminobutyric Acid SCHEMBL1330421 | 0.87 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL190459 | 0.87 | LMNA (1.00) | LMNATSHRBLMGABRR1KMT2A | |
| Gamma-Aminobutyric Acid SCHEMBL3973563 | 0.87 | LMNA (1.00) | LMNATSHRBLMGABRR1KMT2A | |
| Gamma-Aminobutyric Acid SCHEMBL4878 | 0.87 | — | — | |
| Fumaric Acid SCHEMBL1926550 | 0.84 | LMNA (0.50) | LMNATSHRBLMGABRR1KMT2A | |
| Maleic Acid SCHEMBL31557847 | 0.84 | LMNA (0.50) | LMNATSHRBLMGABRR1KMT2A | |
| Gamma-Aminobutyric Acid SCHEMBL25327475 | 0.84 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL587530 | 0.84 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL20593981 | 0.84 | LMNA (0.94) | LMNATSHRBLMGABRR1KMT2A | |
| Gamma-Aminobutyric Acid SCHEMBL20593982 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117356657-A | Feed for improving quality of cow sperm and preparation process thereof | 河南省鼎元种牛育种有限公司 | 2024-01-09 | — | — | CN | claimed |
| CN-114304413-B | Composite containing acidifying agent and preparation method thereof | 云南快大多畜牧科技有限公司 | 2022-12-13 | — | — | CN | claimed |
| CN-114304413-A | Composite containing acidifying agent and preparation method thereof | 福建傲农生物科技集团股份有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-112715756-A | Compound for enhancing immune function and improving intestinal morphology and application thereof | 福建傲农生物科技集团股份有限公司 | 2021-04-30 | — | — | CN | claimed |
| CN-105884637-B | Gamma aminobutyric acid fumarate and its application in additive for animal feed is prepared | 广州先至饲料添加剂有限公司 | 2017-12-12 | — | — | CN | claimed |
| CN-117356657-A | Feed for improving quality of cow sperm and preparation process thereof | 河南省鼎元种牛育种有限公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-114304413-B | Composite containing acidifying agent and preparation method thereof | 云南快大多畜牧科技有限公司 | 2022-12-13 | — | — | CN | disclosed |
| CN-114304413-A | Composite containing acidifying agent and preparation method thereof | 福建傲农生物科技集团股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-112715756-A | Compound for enhancing immune function and improving intestinal morphology and application thereof | 福建傲农生物科技集团股份有限公司 | 2021-04-30 | — | — | CN | disclosed |
| CN-112715756-A | Compound for enhancing immune function and improving intestinal morphology and application thereof | 福建傲农生物科技集团股份有限公司 | 2021-04-30 | — | — | CN | disclosed |
| CN-105884637-B | Gamma aminobutyric acid fumarate and its application in additive for animal feed is prepared | 广州先至饲料添加剂有限公司 | 2017-12-12 | — | — | CN | disclosed |
| CN-105884637-A | Gamma-aminobutyric acid fumarate and application of gamma-aminobutyric acid fumarate in preparation of feed additive for animals | 广州先至饲料添加剂有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-105884637-A | Gamma-aminobutyric acid fumarate and application of gamma-aminobutyric acid fumarate in preparation of feed additive for animals | 广州先至饲料添加剂有限公司 | 2016-08-24 | — | — | CN | disclosed |