Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.50 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | BLM | P54132 | 4/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.50 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.50 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL31557847 | 1.00 | LMNA (0.50) | LMNATSHRBLMGABRR1KMT2A | |
| Beta-Alanine SCHEMBL18281085 | 0.85 | — | — | |
| Beta-Alanine SCHEMBL29449904 | 0.85 | — | — | |
| Beta-Alanine SCHEMBL20411566 | 0.85 | — | — | |
| Beta-Alanine SCHEMBL21500 | 0.85 | — | — | |
| Beta-Alanine SCHEMBL18281080 | 0.85 | — | — | |
| Beta-Alanine SCHEMBL23190 | 0.85 | LMNA (0.65) | LMNATSHRBLMGABRR1KMT2A | |
| Fumaric Acid SCHEMBL28098647 | 0.84 | LMNA (0.75) | LMNATSHRBLMGABRR1KMT2A | |
| Fumaric Acid SCHEMBL18065038 | 0.82 | TSHR (0.64) | LMNATSHRBLMGABRR1KMT2A | |
| Beta-Alanine SCHEMBL9218103 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250152533-A1 | Novel Beta-Alanine Compositions and Methods of Use Thereof | LEGACY CORPORATE LENDING, LLC, AS ADMINISTRATIVE AGENT | 2025-05-15 | — | — | US | disclosed |
| US-7956218-B2 | Organic salts of β-alanine | NORTHERN INNOVATIONS AND FORMULATIONS CORP. (CA) | 2011-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250152533-A1 | Novel Beta-Alanine Compositions and Methods of Use Thereof | GYS1, PYGM, AADAT | KMT2A 4152/4885MEN1 3201/4885SLC6A2 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.