Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | CRHBP | P24387 | 1/20 | 0.65 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.61 |
| ▸ | NOD1 | Q9Y239 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | F10 | P00742 | 2/20 | 0.55 |
| ▸ | CNR2 | P34972 | 4/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28111591 | 0.93 | KDM4E (0.63) | KDM4ECRHBPCRHR2SMN1; SMN2NOD2 | |
| SCHEMBL30585515 | 0.87 | NOD2 (0.64) | KDM4ECRHBPCRHR2SMN1; SMN2NOD2 | |
| SCHEMBL1392918 | 0.87 | NOD2 (0.64) | KDM4ECRHBPCRHR2SMN1; SMN2NOD2 | |
| SCHEMBL7880746 | 0.87 | MTNR1A (0.62) | KDM4ECRHBPCRHR2SMN1; SMN2NOD2 | |
| SCHEMBL1979481 | 0.85 | SMN1; SMN2 (0.48) | KDM4ECRHBPCRHR2SMN1; SMN2NOD2 | |
| SCHEMBL7688465 | 0.85 | CNR2 (0.52) | KDM4ECRHBPCRHR2SMN1; SMN2NOD2 | |
| SCHEMBL6752352 | 0.84 | KDM4E (0.71) | KDM4ECRHBPCRHR2SMN1; SMN2NOD2 | |
| SCHEMBL18322286 | 0.83 | KDM4E (0.73) | KDM4ECRHBPCRHR2SMN1; SMN2NOD2 | |
| SCHEMBL13742183 | 0.83 | KDM4E (0.70) | KDM4ECRHBPCRHR2SMN1; SMN2NOD2 | |
| SCHEMBL30489155 | 0.83 | KDM4E (0.73) | KDM4ECRHBPCRHR2SMN1; SMN2NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103992326-B | Indole hexahydropyrazine quinazolinone anti-tumor compounds and preparation method thereof | 中国人民解放军第二军医大学 | 2016-09-28 | — | — | CN | claimed |
| CN-103992326-B | Indole hexahydropyrazine quinazolinone anti-tumor compounds and preparation method thereof | 中国人民解放军第二军医大学 | 2016-09-28 | — | — | CN | disclosed |