Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29290952 | 0.83 | SMN1; SMN2 (0.41) | CRBNPOLBSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL28209858 | 0.83 | SMN1; SMN2 (0.34) | CRBNPOLBSMN1; SMN2ALDH1A1EP300 | |
| SCHEMBL29290943 | 0.81 | KDM4E (0.36) | CRBNPOLBSMN1; SMN2ALDH1A1EP300 | |
| SCHEMBL29290948 | 0.80 | SLC11A2 (0.34) | CRBNPTK2POLBSMN1; SMN2MAPT | |
| SCHEMBL20688977 | 0.78 | MAP4K4 (0.38) | CRBNCHEK1AURKADAPK3JAK2 | |
| SCHEMBL29290944 | 0.78 | KDM4E (0.34) | FLT3POLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL27504274 | 0.72 | POLB (0.37) | CRBNCHEK1AURKADAPK3JAK2 | |
| SCHEMBL28565280 | 0.71 | SMN1; SMN2 (0.34) | CRBNPOLBSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18885095 | 0.66 | CRBN (0.38) | CRBNSMN1; SMN2ALDH1A1PLD1MAPT | |
| SCHEMBL29290947 | 0.66 | SMN1; SMN2 (0.41) | CRBNPOLBSMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105992768-B | The Imidazopyridazine compounds of conditioning agent as the response of IL 12, IL 23 and/or IFN α | 百时美施贵宝公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-105992768-A | Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses | 百时美施贵宝公司 | 2016-10-05 | — | — | CN | disclosed |