Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.33 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27522973 | 0.75 | POLB (0.35) | POLBSMN1; SMN2EP300KAT2BCRBN | |
| SCHEMBL29290947 | 0.75 | SMN1; SMN2 (0.41) | POLBSMN1; SMN2EP300KAT2BCRBN | |
| SCHEMBL29290942 | 0.75 | SMN1; SMN2 (0.41) | POLBSMN1; SMN2EP300KAT2BRAB9A | |
| SCHEMBL29290945 | 0.75 | POLB (0.35) | POLBSMN1; SMN2EP300KAT2BKDM4E | |
| SCHEMBL27689215 | 0.74 | HTR1A (0.44) | — | |
| SCHEMBL27520393 | 0.73 | KDM4E (0.34) | POLBSMN1; SMN2EP300KAT2BRAB9A | |
| SCHEMBL29290952 | 0.72 | SMN1; SMN2 (0.41) | POLBSMN1; SMN2EP300KAT2BCRBN | |
| SCHEMBL28291648 | 0.72 | ALDH1A1 (0.41) | SMN1; SMN2CRBNCYP1A2KDM4EALDH1A1 | |
| SCHEMBL28099962 | 0.72 | CRBN (0.35) | POLBSMN1; SMN2EP300KAT2BCRBN | |
| SCHEMBL28209858 | 0.72 | SMN1; SMN2 (0.34) | POLBSMN1; SMN2EP300KAT2BCRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285799-A | 2H- [1,2′-bipyridine]Synthesis method of (E) -2-ketone compound | 五邑大学 | 2020-06-16 | — | — | CN | claimed |
| CN-111285799-A | 2H- [1,2′-bipyridine]Synthesis method of (E) -2-ketone compound | 五邑大学 | 2020-06-16 | — | — | CN | disclosed |
| CN-111285799-A | 2H- [1,2′-bipyridine]Synthesis method of (E) -2-ketone compound | 五邑大学 | 2020-06-16 | — | — | CN | disclosed |
| CN-109678854-A | A kind of method that manganese catalyzes and synthesizes pyrido [1,2-a] indoles -6 (1H) -one class compound | 陕西师范大学 | 2019-04-26 | — | — | CN | disclosed |
| CN-1245386-C | 1, 2-dihydropyridine compound, preparation method and application thereof | EISAI CO LTD (JP) | 2006-03-15 | — | — | CN | disclosed |
| CN-1436172-A | 1, 2-dihydropyridine compound, preparation method and application thereof | EISAI CO LTD (JP) | 2003-08-13 | — | — | CN | disclosed |