Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SLC11A2 | P49281 | 3/20 | 0.35 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28209858 | 0.83 | SMN1; SMN2 (0.34) | SMN1; SMN2KDM4ESLC11A2ALKBH2EGLN1 | |
| SCHEMBL28099962 | 0.83 | CRBN (0.35) | SMN1; SMN2KDM4EALKBH2EGLN1MAPT | |
| SCHEMBL29290943 | 0.81 | KDM4E (0.36) | SMN1; SMN2PDCD1CD274KDM4ESLC11A2 | |
| SCHEMBL29290948 | 0.80 | SLC11A2 (0.34) | SMN1; SMN2PDCD1CD274KDM4ESLC11A2 | |
| SCHEMBL29290944 | 0.78 | KDM4E (0.34) | SMN1; SMN2PDCD1CD274KDM4ESLC11A2 | |
| SCHEMBL27504274 | 0.72 | POLB (0.37) | SMN1; SMN2PDCD1CD274KDM4ESLC11A2 | |
| SCHEMBL28565280 | 0.71 | SMN1; SMN2 (0.34) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 | |
| SCHEMBL29290947 | 0.71 | SMN1; SMN2 (0.41) | SMN1; SMN2PDCD1CD274KDM4ESLC11A2 | |
| SCHEMBL29290942 | 0.69 | SMN1; SMN2 (0.41) | SMN1; SMN2PDCD1CD274KDM4ESLC11A2 | |
| SCHEMBL20688977 | 0.66 | MAP4K4 (0.38) | SMN1; SMN2KDM4EALKBH2EGLN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109678854-A | A kind of method that manganese catalyzes and synthesizes pyrido [1,2-a] indoles -6 (1H) -one class compound | 陕西师范大学 | 2019-04-26 | — | — | CN | disclosed |