Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14387378 | 0.98 | KMT2A (0.49) | KMT2AMEN1NPSR1L3MBTL1HSP90AA1 | |
| Bromide SCHEMBL5148139 | 0.97 | KMT2A (0.47) | KMT2AMEN1NPSR1L3MBTL1HSP90AA1 | |
| Fluoride Ion SCHEMBL5148077 | 0.97 | KMT2A (0.47) | KMT2AMEN1NPSR1L3MBTL1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL2810174 | 0.85 | NPSR1 (0.55) | KMT2AMEN1NPSR1L3MBTL1HSP90AA1 | |
| Bromide SCHEMBL9432590 | 0.84 | ALDH1A1 (0.45) | KMT2AMEN1NPSR1L3MBTL1HSP90AA1 | |
| SCHEMBL11383237 | 0.83 | USP2 (0.50) | KMT2AMEN1NPSR1L3MBTL1HSP90AA1 | |
| Fluoride Ion SCHEMBL5149210 | 0.82 | NPSR1 (0.55) | KMT2AMEN1NPSR1L3MBTL1HSP90AA1 | |
| Bromide SCHEMBL5149080 | 0.82 | NPSR1 (0.55) | KMT2AMEN1NPSR1L3MBTL1HSP90AA1 | |
| SCHEMBL9811331 | 0.79 | KMT2A (0.53) | KMT2AMEN1NPSR1L3MBTL1HSP90AA1 | |
| Bromide SCHEMBL8588064 | 0.78 | HSP90AA1 (0.45) | KMT2AMEN1NPSR1L3MBTL1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3972787-A | Palladium electrolyte baths utilizing quaternized pyridine compounds as brighteners | LEA-RONAL, INC. (US) | 1976-08-03 | — | — | US | claimed |
| US-20100236936-A1 | Aqueous,alkaline,cyanide-free bath for the galvanic deposition of zinc and zinc alloy coatings | ATOTECH DEUTSCHLAND GMBH (DE) | 2010-09-23 | — | — | US | disclosed |
| US-20100155257-A1 | Aqueous, alkaline, cyanide-free bath for the galvanic deposition of zinc alloy coatings | ATOTECH DEUTSCHLAND GMBH (DE) | 2010-06-24 | — | — | US | disclosed |
| EP-1870495-A1 | Aqueous alkaline, cyanide-free, bath for the galvanic deposition of Zinc and Zinc alloy layers | ATOTECH DEUTSCHLAND GMBH (DE) | 2007-12-26 | — | — | EP | disclosed |
| US-3972787-A | Palladium electrolyte baths utilizing quaternized pyridine compounds as brighteners | LEA-RONAL, INC. (US) | 1976-08-03 | — | — | US | disclosed |