Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28160344 | 0.75 | PTGS2 (0.49) | PTGS2NR1H2NR1H3RXRAPTGDR2 | |
| SCHEMBL9317262 | 0.75 | HSD11B1 (0.43) | MAP4K4SLC22A12ALOX5APFEN1 | |
| SCHEMBL28111372 | 0.75 | PTGS2 (0.58) | PTGS2NR1H2NR1H3PTGS1 | |
| SCHEMBL5350907 | 0.74 | PTGS2 (0.63) | PIK3CAMAP4K4KCNH2MINK1PI4KB | |
| SCHEMBL31332078 | 0.73 | HRH4 (0.43) | PIK3CAMAP4K4KCNH2MINK1PI4KB | |
| SCHEMBL28160376 | 0.73 | PTGS2 (0.54) | PTGS2NR1H2NR1H3PTGDR2PTGS1 | |
| SCHEMBL6514474 | 0.72 | FFAR4 (0.54) | PIK3CAMAP4K4KCNH2MINK1PI4KB | |
| SCHEMBL1255100 | 0.71 | SLC22A12 (0.43) | NR1H2NR1H3SLC22A12 | |
| SCHEMBL2223573 | 0.70 | KCNH2 (0.71) | PIK3CAMAP4K4KCNH2MINK1PI4KB | |
| SCHEMBL5701303 | 0.69 | ALOX5AP (0.49) | MAP4K4PTGS2PTGS1ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106188040-A | A kind of Fevipiprant and the preparation method of intermediate thereof | 浙江宏鑫染化材料有限公司 | 2016-12-07 | — | — | CN | claimed |
| CN-106188040-B | A kind of Fevipiprant and its intermediate preparation method | 浙江宏鑫染化材料有限公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-106188040-A | A kind of Fevipiprant and the preparation method of intermediate thereof | 浙江宏鑫染化材料有限公司 | 2016-12-07 | — | — | CN | disclosed |