Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38663324 | 0.86 | LMNA (0.58) | LMNAF2TSHRTDP1TP53 | |
| SCHEMBL9561745 | 0.82 | ALOX15 (0.39) | TSHRTDP1PARP10NSD2HSD17B10 | |
| SCHEMBL28326886 | 0.78 | LMNA (0.50) | LMNAF2TSHRTDP1TP53 | |
| SCHEMBL28120446 | 0.78 | ELANE (0.40) | LMNATSHRTDP1MAPTALDH1A1 | |
| SCHEMBL27447997 | 0.78 | PARP10 (0.41) | LMNATSHRTDP1KMT2AMAPT | |
| SCHEMBL28937233 | 0.78 | TSHR (0.57) | LMNAF2TSHRTDP1TP53 | |
| SCHEMBL11228311 | 0.77 | LMNA (0.58) | LMNAF2TSHRTDP1TP53 | |
| SCHEMBL1878004 | 0.76 | CA1 (0.46) | LMNATSHRALDH1A1 | |
| SCHEMBL28089056 | 0.76 | CA1 (0.33) | TSHRSMN1; SMN2AKR1C3RAB9A | |
| SCHEMBL28064761 | 0.76 | MTNR1A (0.44) | LMNATSHRTDP1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146511-A | Pyrazolopyrimidine derivative, preparation method, pharmaceutical composition and purposes | 安润医药科技（苏州）有限公司 | 2016-11-23 | — | — | CN | disclosed |