Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28113310 | 0.88 | ALDH1A1 (0.47) | TDP1KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL27487116 | 0.88 | CFTR (0.41) | TDP1CFTRKDM4EMAPTALDH1A1 | |
| SCHEMBL7751795 | 0.77 | MAPT (0.49) | TDP1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL498352 | 0.76 | LOXL2 (0.46) | MAPTRAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12244969 | 0.75 | MAPT (0.56) | CFTRKDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL24901813 | 0.74 | CFTR (0.67) | CFTRKDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL2111264 | 0.72 | KMT2A (0.45) | CFTRKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5354905 | 0.72 | CFTR (0.51) | CFTRKDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL1546535 | 0.71 | TDP1 (0.57) | TDP1CFTRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2006535 | 0.71 | KDM4E (0.41) | TDP1CFTRKDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110143950-A | Medical compounds | 西雅图遗传学公司 | 2019-08-20 | — | — | CN | disclosed |
| CN-106170288-B | Pharmaceutical compounds | 西雅图遗传学公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-106170288-A | Pharmaceutical compounds | 卡斯卡迪安疗法公司 | 2016-11-30 | — | — | CN | disclosed |