Toluene

Toluene

SCHEMBL28113553

COc1ccc(O)cc1OC.Cc1ccccc1

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.53
ACHE P22303 3/20 0.52
CYP1A1 P04798 2/20 0.46
CYP1A2 P05177 2/20 0.46
CYP1B1 Q16678 1/20 0.46
CA1 P00915 3/20 0.44
CA2 P00918 3/20 0.44
CA12 O43570 2/20 0.44
CA4 P22748 2/20 0.44
CA7 P43166 2/20 0.44
CA9 Q16790 2/20 0.44
CA14 Q9ULX7 2/20 0.44
PTGS1 P23219 1/20 0.44
PTGS2 P35354 1/20 0.44
CA6 P23280 1/20 0.44
TPMT P51580 1/20 0.44
MAPT P10636 3/20 0.44
CTNNB1 P35222 2/20 0.44
WNT3A P56704 2/20 0.44
ALDH1A1 P00352 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL119396 0.85 MAOB (0.70) MAOBACHECYP1A1CYP1A2CA1
SCHEMBL30514387 0.85 MAOB (0.70) MAOBACHECYP1A1CYP1A2CA1
Methane SCHEMBL27404638 0.83 MAOB (0.67) MAOBACHECYP1A1CYP1A2CA1
1,2-Dimethoxybenzene SCHEMBL27479591 0.79 CA1 (0.72) ACHECA1CA2CA12CA4
Hydroquinone SCHEMBL27268188 0.77 ACHE (0.60) ACHECYP1A2CA1CA2CA12
SCHEMBL31444153 0.77 BCHE (0.63) ALDH1A1HPGDKDM4ERAB9AKMT2A
SCHEMBL6881536 0.77 BCHE (0.63) CYP1A2HPGDKDM4EMEN1RAB9A
SCHEMBL6035592 0.77 BCHE (0.63) ALDH1A1HPGDKDM4ERAB9AKMT2A
Catechol SCHEMBL28616324 0.74 ACHE (0.72) ACHECYP1A2CA1CA2MAPT
Mequinol SCHEMBL28799186 0.74 LTA4H (0.61) ACHECA1CA2CA12CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106316979-B A kind of preparation method of acotiamide hydrochloride hydrate 山东罗欣药业集团股份有限公司 2018-11-27 CN disclosed
CN-106316979-A Acotiamide hydrochloride preparation method 山东罗欣药业集团股份有限公司 2017-01-11 CN disclosed