SCHEMBL28113571

SCHEMBL28113571

COc1ccc(N)c(-c2ccc(Br)cc2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.49
HDAC1 Q13547 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
CYP3A4 P08684 4/20 0.47
ALDH1A1 P00352 4/20 0.47
ACHE P22303 2/20 0.47
CYP1A2 P05177 2/20 0.45
CYP2D6 P10635 2/20 0.45
CYP2C9 P11712 2/20 0.45
CYP2C19 P33261 2/20 0.45
CYP11B1 P15538 1/20 0.45
CYP11B2 P19099 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.43
RELA Q04206 3/20 0.43
TP53 P04637 1/20 0.43
NFKB1 P19838 1/20 0.43
NFKB2 Q00653 1/20 0.43
MEN1 O00255 5/20 0.43
KMT2A Q03164 5/20 0.43
MAPT P10636 5/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3789140 0.85 TDP1 (0.56) CYP3A4ALDH1A1CYP1A2CYP2D6CYP2C9
SCHEMBL1578362 0.82 MEN1 (0.50) CYP3A4ALDH1A1CYP1A2CYP2D6CYP2C9
SCHEMBL21708253 0.82 RELA (0.55) CYP3A4ALDH1A1CYP1A2CYP2D6CYP2C9
SCHEMBL3785577 0.81 ALDH1A1 (0.50) HDAC8CYP3A4ALDH1A1CYP1A2CYP2D6
SCHEMBL29492486 0.81 ALDH1A1 (0.50) HDAC8CYP3A4ALDH1A1CYP1A2CYP2D6
SCHEMBL30610973 0.81 HDAC3 (0.51) HDAC3HDAC1HDAC8ACHECYP1A2
SCHEMBL11004268 0.80 ALDH1A1 (0.61) CYP3A4ALDH1A1CYP1A2CYP2D6CYP2C9
SCHEMBL30206743 0.80 ALDH1A1 (0.61) CYP3A4ALDH1A1CYP1A2CYP2D6CYP2C9
SCHEMBL30206740 0.80 ALDH1A1 (0.61) CYP3A4ALDH1A1CYP1A2CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL654303 0.80 ALDH1A1 (0.53) HDAC8CYP3A4ALDH1A1CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106883382-A Organic semiconductor composition 斯马特凯姆有限公司 2017-06-23 CN disclosed
CN-104204058-B Organic semiconductor composition 斯马特凯姆有限公司 2016-11-09 CN disclosed