Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL10918077 | 0.92 | ALDH1A1 (0.54) | MAPTKMOTSHRHPGDALDH1A1 | |
| Bicarbonate SCHEMBL8773620 | 0.80 | SMN1; SMN2 (0.48) | MAPTKDM4ETP53TSHRALDH1A1 | |
| SCHEMBL60648 | 0.80 | KMO (0.67) | MAPTKMOKDM4ETP53TSHR | |
| SCHEMBL63450 | 0.78 | CHEK1 (0.70) | MAPTKDM4ETP53CHEK1USP2 | |
| SCHEMBL4696938 | 0.78 | HPGD (0.72) | MAPTKDM4ETSHRPOLBHPGD | |
| Hydrochloric Acid SCHEMBL6186324 | 0.78 | KMO (0.65) | MAPTKMOKDM4ETP53TSHR | |
| Bicarbonate SCHEMBL28061158 | 0.78 | SMN1; SMN2 (0.46) | HRH3KDM4ETP53TSHRALDH1A1 | |
| Acetic Acid SCHEMBL5163643 | 0.78 | SMN1; SMN2 (0.52) | HRH3KDM4ETP53TSHRALDH1A1 | |
| Terephthalic Acid SCHEMBL2049859 | 0.78 | TSHR (0.71) | MAPTTP53TSHRHPGDALDH1A1 | |
| Hydrogen Peroxide SCHEMBL11793831 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104017196-B | Polycarbonate copolymer, coating liquid using same, and electrophotographic photoreceptor | 出光兴产株式会社 | 2016-12-07 | — | — | CN | disclosed |