Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28604972 | 0.85 | ALDH1A1 (0.47) | ALDH1A1HIF1AVCAM1SMN1; SMN2GRM8 | |
| SCHEMBL7383304 | 0.83 | ALDH1A1 (0.51) | ALDH1A1HIF1AVCAM1SMN1; SMN2GRM8 | |
| SCHEMBL257444 | 0.78 | VCAM1 (0.51) | ALDH1A1HIF1AVCAM1SMN1; SMN2GRM8 | |
| SCHEMBL12868652 | 0.77 | ALDH1A1 (0.56) | ALDH1A1HIF1AVCAM1SMN1; SMN2GRM8 | |
| SCHEMBL11490458 | 0.76 | VCAM1 (0.42) | ALDH1A1HIF1AVCAM1BCHEACHE | |
| SCHEMBL2647682 | 0.76 | ALDH1A1 (0.47) | ALDH1A1HIF1AVCAM1SMN1; SMN2GRM8 | |
| SCHEMBL2698568 | 0.75 | ALDH1A1 (0.58) | ALDH1A1HIF1AVCAM1SMN1; SMN2GRM8 | |
| SCHEMBL30155394 | 0.75 | ALDH1A1 (0.58) | ALDH1A1HIF1AVCAM1SMN1; SMN2GRM8 | |
| SCHEMBL10347723 | 0.75 | ALDH1A1 (0.50) | ALDH1A1HIF1AVCAM1SMN1; SMN2GRM8 | |
| SCHEMBL27624872 | 0.75 | ALDH1A1 (0.54) | ALDH1A1HIF1AVCAM1SMN1; SMN2GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106187904-B | Propiolamido-containing 2-phenylimidazole derivative and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2021-07-06 | — | — | CN | claimed |
| CN-106187904-A | 2-phenylimidazole analog derivative containing propioloyl amido and preparation method thereof and pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2016-12-07 | — | — | CN | claimed |
| CN-106187904-B | Propiolamido-containing 2-phenylimidazole derivative and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2021-07-06 | — | — | CN | disclosed |
| CN-106187904-A | 2-phenylimidazole analog derivative containing propioloyl amido and preparation method thereof and pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2016-12-07 | — | — | CN | disclosed |