Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyrimidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimidine SCHEMBL28058723 | 0.84 | CYP1A2 (0.53) | TSHRNFKB1CYP3A4LMNACA2 | |
| Pyrimidine SCHEMBL28421059 | 0.83 | F7 (0.42) | TSHRCYP3A4LMNARECQLF7 | |
| Pyrimidine SCHEMBL374258 | 0.83 | F7 (0.42) | TSHRCYP3A4LMNARECQLF7 | |
| Pyrimidine SCHEMBL27471792 | 0.82 | RECQL (0.37) | TSHRNFKB1CYP3A4LMNACA2 | |
| Pyrimidine SCHEMBL28845102 | 0.80 | F7 (0.41) | TSHRLMNARECQLF7F3 | |
| Pyrimidine SCHEMBL28103116 | 0.80 | F7 (0.41) | TSHRLMNARECQLF7F3 | |
| Pyrimidine SCHEMBL28248566 | 0.80 | F7 (0.41) | TSHRLMNARECQLF7F3 | |
| Pyrimidine SCHEMBL28643613 | 0.80 | F7 (0.46) | TSHRRECQLF7F3SARM1 | |
| Pyrimidine SCHEMBL1150634 | 0.80 | F7 (0.46) | TSHRRECQLF7F3SARM1 | |
| Pyrimidine SCHEMBL28121327 | 0.80 | F7 (0.41) | TSHRLMNARECQLF7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110461345-A | Oral compositions comprising lactic acid bacteria for modulating immune responses and methods related thereto | UNIV CALIFORNIA | 2019-11-15 | — | — | CN | disclosed |
| CN-109689062-A | Use the method for the combined therapy PTEN deficiency epithelioma of anti-PI3K β and anti-immunity checkpoint medicament | 丹娜法伯癌症研究院 | 2019-04-26 | — | — | CN | disclosed |
| CN-107106669-A | Composition and method for treating the cancer for over-expressing the α of HIF 1 | 南加利福尼亚大学 | 2017-08-29 | — | — | CN | disclosed |
| CN-106413738-A | Receptor targeting constructs and uses thereof | 席德-西奈医疗中心 | 2017-02-15 | — | — | CN | disclosed |
| CN-106232878-A | The biomarker of MELK activity and the method that uses it | 丹娜法伯癌症研究院 | 2016-12-14 | — | — | CN | disclosed |