Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorobenzene SCHEMBL10599852 | 0.85 | NR4A2 (0.45) | NR4A2HTTKEAP1ALDH1A1CYP2C19 | |
| Fluorobenzene SCHEMBL5765024 | 0.84 | KEAP1 (0.45) | NR4A2HTTKEAP1ALDH1A1CYP2C19 | |
| Fluorobenzene SCHEMBL27954093 | 0.84 | HDAC3 (0.56) | NR4A2HTTKEAP1ALDH1A1FFAR1 | |
| Fluorobenzene SCHEMBL27579731 | 0.82 | AKR1B1 (0.44) | NR4A2KEAP1ALDH1A1FFAR1LMNA | |
| Fluorobenzene SCHEMBL28144868 | 0.81 | KCNN4 (0.48) | ALDH1A1RAB9ATSHR | |
| Fluorobenzene SCHEMBL5865256 | 0.81 | KCNN4 (0.48) | ALDH1A1RAB9ATSHR | |
| Valeric Acid SCHEMBL27728287 | 0.81 | HTR7 (0.56) | ALDH1A1FFAR1SMN1; SMN2HDAC3HDAC4 | |
| Fluorobenzene SCHEMBL10979592 | 0.80 | FFAR3 (0.50) | HTTALDH1A1CYP2C19SMN1; SMN2RAB9A | |
| Fluorobenzene SCHEMBL27923888 | 0.80 | GLRA1 (0.50) | ALDH1A1FFAR1SMN1; SMN2RAB9AHDAC1 | |
| Fluorobenzene SCHEMBL10512632 | 0.79 | PAM (0.45) | NR4A2HTTALDH1A1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106187863-A | The preparation method of penfluridol | 湖南中南制药有限责任公司 | 2016-12-07 | — | — | CN | disclosed |