Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28116804 | 0.84 | NR4A2 (0.54) | KEAP1NR4A2FFAR1MAPK1HDAC3 | |
| Fluorobenzene SCHEMBL27954093 | 0.83 | HDAC3 (0.56) | KEAP1NR4A2FFAR1MAPK1HDAC3 | |
| R-Chloropropionate SCHEMBL10922210 | 0.81 | LMNA (0.50) | KEAP1NR4A2FFAR1MAPK1HDAC3 | |
| Phenol SCHEMBL28036694 | 0.80 | CA2 (0.50) | KEAP1NR4A2FFAR1MAPK1HDAC3 | |
| R-Chloropropionate SCHEMBL9049894 | 0.77 | CYP3A4 (0.50) | KEAP1NR4A2FFAR1MAPK1HDAC3 | |
| R-Chloropropionate SCHEMBL27926601 | 0.77 | FFAR1 (0.50) | KEAP1NR4A2FFAR1MAPK1HDAC3 | |
| Fluorobenzene SCHEMBL27579731 | 0.77 | AKR1B1 (0.44) | KEAP1NR4A2FFAR1ALDH1A1 | |
| Fluorobenzene SCHEMBL28280264 | 0.76 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1TSHRMAPTMEN1 | |
| Fluorobenzene SCHEMBL9441778 | 0.76 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1TSHRMAPTMEN1 | |
| Fluorobenzene SCHEMBL27550803 | 0.76 | ALDH1A1 (0.46) | MAPK1SMN1; SMN2HTTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651637-A1 | 3-AMINO CHROMAN AND 2-AMINO TETRALIN DERIVATIVES | Wyeth (US) | 2006-05-03 | — | — | EP | disclosed |
| US-20050032873-A1 | 3-Amino chroman and 2-amino tetralin derivatives | WYETH (US) | 2005-02-10 | — | — | US | disclosed |
| WO-2005012291-A1 | 3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES | WYETH (US) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032873-A1 | 3-Amino chroman and 2-amino tetralin derivatives | TPH2, HTR2C, HTR7 | KEAP1 3970/4885NR4A2 1360/4885FFAR1 2080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.