SCHEMBL28116874

SCHEMBL28116874

COC(NC(=O)c1cncnc1)OC

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.42
ACACB O00763 1/20 0.41
CTSL P07711 1/20 0.41
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
XDH P47989 5/20 0.38
ALDH1A1 P00352 3/20 0.37
ATM Q13315 1/20 0.37
BCAT2 O15382 1/20 0.36
CYP1A2 P05177 2/20 0.36
CYP3A4 P08684 2/20 0.36
KDM4E B2RXH2 1/20 0.35
HSD17B10 Q99714 1/20 0.35
BDKRB1 P46663 2/20 0.34
CHRM2 P08172 1/20 0.34
GRM5 P41594 1/20 0.34
SIGMAR1 Q99720 1/20 0.34
ITGAV P06756 1/20 0.34
HPGDS O60760 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15646784 0.82 XDH (0.51) HCAR2ACACBCTSLXDHALDH1A1
SCHEMBL27877527 0.80 MEN1 (0.62) MEN1KMT2AALDH1A1CYP1A2CYP3A4
SCHEMBL27822263 0.78 ALDH1A1 (0.53) MEN1KMT2AALDH1A1CYP1A2CYP3A4
SCHEMBL10671315 0.77 HCAR2 (0.45) HCAR2ACACBCTSLMEN1KMT2A
SCHEMBL3436067 0.75 CTSL (0.45) ACACBCTSLALDH1A1KDM4EHSD17B10
SCHEMBL8380943 0.73 GAA (0.53) MEN1KMT2AALDH1A1CYP1A2CYP3A4
SCHEMBL28159463 0.71 KDM4E (0.51) HCAR2MEN1KMT2AALDH1A1CYP1A2
SCHEMBL669122 0.71 HCAR2 (0.58) HCAR2ALDH1A1BCAT2KDM4EGRM5
SCHEMBL2491694 0.71 ALDH1A1 (0.59) HCAR2XDHALDH1A1ATMKDM4E
SCHEMBL5768937 0.70 KMT2A (0.42) HCAR2CTSLMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106231901-A Metal enzyme inhibitor compound as antifungal 美国陶氏益农公司 2016-12-14 CN disclosed