SCHEMBL28118480

SCHEMBL28118480

NS(=O)(=O)c1cccc(-n2ncc3ccccc32)c1

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 2/20 0.57
CDK1 P06493 2/20 0.57
CCNB1 P14635 2/20 0.57
CDK9 P50750 2/20 0.57
CYP17A1 P05093 4/20 0.52
CA1 P00915 8/20 0.49
CA2 P00918 8/20 0.49
CA9 Q16790 6/20 0.49
CA12 O43570 3/20 0.49
CDK7 P50613 1/20 0.48
CCNH P51946 1/20 0.48
GRM1 Q13255 1/20 0.47
LMNA P02545 2/20 0.46
CA7 P43166 2/20 0.43
CYP11B1 P15538 1/20 0.42
CYP11B2 P19099 1/20 0.42
LRRK2 Q5S007 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18812725 0.81 HPGD (0.48) CCNT1CDK1CCNB1CDK9CYP17A1
SCHEMBL28161420 0.79 ALDH1A1 (0.52) LMNA
SCHEMBL2627244 0.77 IRAK4 (0.53) CYP11B1CYP11B2LRRK2
SCHEMBL30032844 0.77 HPGD (0.54) GRM1LMNACYP11B1CYP11B2LRRK2
SCHEMBL29845679 0.77 IRAK4 (0.53) CYP11B1CYP11B2LRRK2
SCHEMBL30918020 0.74 CYP11B2 (0.54) CYP11B1CYP11B2LRRK2
SCHEMBL18289116 0.74 CYP11B2 (0.47) LMNACYP11B1CYP11B2LRRK2
SCHEMBL30186312 0.74 NR3C1 (0.51) CYP11B1CYP11B2LRRK2
SCHEMBL2548808 0.74 KHK (0.56) CYP11B1CYP11B2LRRK2
SCHEMBL16634158 0.74 NR3C1 (0.51) CYP11B1CYP11B2LRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106397217-A Method for synthesizing dextral alpha-cyclohexylbenzylamine 王际菊 2017-02-15 CN disclosed
CN-106397218-A S-alpha-cyclohexyl benzene methanamine 王际菊 2017-02-15 CN disclosed