Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27934280 | 0.95 | ALDH1A1 (0.42) | ALDH1A1ESR1KMT2AMEN1EGLN1 | |
| D-Glutamate SCHEMBL28132769 | 0.89 | ARG1 (0.38) | ALDH1A1ESR1KMT2AEGLN1LMNA | |
| Quinoline SCHEMBL28143672 | 0.89 | LMNA (0.44) | ALDH1A1ESR1KMT2ALMNAKDM4E | |
| Glycine SCHEMBL28141302 | 0.85 | ESR1 (0.37) | ESR1LMNA | |
| SCHEMBL28120475 | 0.80 | ESR1 (0.41) | ESR1LMNA | |
| Quinoline SCHEMBL27876757 | 0.79 | ALDH1A1 (0.42) | ALDH1A1LMNAHTR2ADRD3KDM4E | |
| Quinoline SCHEMBL7173747 | 0.78 | ALDH1A1 (0.63) | ALDH1A1KMT2AMEN1LMNAHDAC3 | |
| Quinoline SCHEMBL27758094 | 0.76 | ALDH1A1 (0.42) | ALDH1A1KMT2AMEN1HTR1AHTR2A | |
| Quinoline SCHEMBL27593667 | 0.74 | ALDH1A1 (0.49) | ALDH1A1KMT2A | |
| Quinoline SCHEMBL27289555 | 0.74 | ALDH1A1 (0.49) | ALDH1A1ESR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110382655-A | Processing medium, processing composition and processing method | 帕莱斯化学株式会社 | 2019-10-25 | — | — | CN | disclosed |
| CN-109789077-A | Composition for oral cavity | 狮王株式会社 | 2019-05-21 | — | — | CN | disclosed |
| CN-108348477-A | Transdermic absorbent delivery device and its manufacturing method | 美德阿利克斯株式会社 | 2018-07-31 | — | — | CN | disclosed |
| CN-107921007-A | Patch | 株式会社钟化 | 2018-04-17 | — | — | CN | disclosed |
| CN-107708657-A | Liquid skin cleaning agent | 花王株式会社 | 2018-02-16 | — | — | CN | disclosed |
| CN-107613948-A | oral composition | 狮王株式会社 | 2018-01-19 | — | — | CN | disclosed |
| CN-107405312-A | Transdermic absorbent delivery device and its manufacture method | 美德阿利克斯株式会社 | 2017-11-28 | — | — | CN | disclosed |
| CN-103957879-B | Oral composition | 狮王株式会社 | 2017-08-08 | — | — | CN | disclosed |
| CN-106687508-A | Silicone emulsions | 道康宁公司 | 2017-05-17 | — | — | CN | disclosed |
| CN-104159568-B | sunscreen composition | 大塚制药株式会社 | 2017-05-03 | — | — | CN | disclosed |
| CN-106572952-A | Hair composition | 太阳星光齿磨公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-106572957-A | Skin color-improving agent and composition for improving skin color | 昭和电工株式会社 | 2017-04-19 | — | — | CN | disclosed |