Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 2/20 | 0.36 |
| ▸ | ARG1 | P05089 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 2/20 | 0.33 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | GABRE | P78334 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28120475 | 0.94 | ESR1 (0.41) | ESR1SMN1; SMN2FPR2ARG1ALPG | |
| Quinoline SCHEMBL28118748 | 0.85 | ALDH1A1 (0.39) | ESR1LMNA | |
| SCHEMBL29651715 | 0.83 | ARG1 (0.42) | ESR1SMN1; SMN2FPR2ARG1 | |
| Glycine SCHEMBL28102155 | 0.79 | ALDH1A1 (0.49) | ESR1SMN1; SMN2ARG1ALPGPLAA | |
| SCHEMBL3383201 | 0.79 | ESR1 (0.35) | ESR1SMN1; SMN2FPR2ARG1ALPG | |
| SCHEMBL28055085 | 0.79 | SMN1; SMN2 (0.35) | ESR1SMN1; SMN2FPR2LMNA | |
| Quinoline SCHEMBL27934280 | 0.78 | ALDH1A1 (0.42) | ESR1LMNA | |
| SCHEMBL8382367 | 0.78 | KCNH2 (0.34) | ALPGPLAAALPL | |
| SCHEMBL27978839 | 0.75 | SMN1; SMN2 (0.45) | ESR1SMN1; SMN2FPR2ALPGPLAA | |
| SCHEMBL17865370 | 0.74 | KCNH2 (0.41) | ESR1SMN1; SMN2FPR2ALPGPLAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108700807-A | Positive photosensitive siloxane composition | AZ电子材料（卢森堡）有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-104955771-B | Metal oxide mesomorphic body and its manufacturing method | 国立研究开发法人科学技术振兴机构 | 2018-06-15 | — | — | CN | disclosed |
| CN-104717955-B | Dentrifice composition and remineralization of teeth accelerating agent | 狮王株式会社 | 2018-04-27 | — | — | CN | disclosed |
| CN-104854168-B | Composite of silicon oxide nanoparticles and silsesquioxane polymer, method for producing same, and composite material produced using composite thereof | AZ电子材料（卢森堡）有限公司 | 2017-04-12 | — | — | CN | disclosed |