Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28119211 | 0.88 | IDO1 (0.47) | ATMGSK3BNQO2TP53SMN1; SMN2 | |
| SCHEMBL28119199 | 0.83 | KIF11 (0.50) | ATMHTTMEN1KMT2AMAPT | |
| SCHEMBL28837904 | 0.79 | NQO2 (0.47) | GSK3BNQO2SMN1; SMN2BRD4MEN1 | |
| SCHEMBL28119198 | 0.79 | NQO2 (0.47) | GSK3BNQO2HTTBRD4MEN1 | |
| SCHEMBL28119197 | 0.78 | NQO2 (0.46) | GSK3BNQO2HTTBRD4MEN1 | |
| SCHEMBL2495439 | 0.76 | IDO1 (0.62) | ATMTP53SMN1; SMN2PGRPIK3CD | |
| SCHEMBL17166881 | 0.76 | ATM (0.55) | ATMGSK3BTP53SMN1; SMN2PGR | |
| SCHEMBL15426102 | 0.76 | TP53 (0.67) | ATMTP53SMN1; SMN2PGRPIK3CD | |
| SCHEMBL12165522 | 0.74 | ATM (0.77) | ATMSMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL28874851 | 0.70 | KCNH3 (0.39) | TP53MEN1POLBKMT2APDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | claimed |
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | disclosed |