Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 9/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28118833 | 0.83 | ATM (0.47) | ATMMEN1MAPTKMT2AHTT | |
| SCHEMBL28118828 | 0.82 | KIF11 (0.48) | KIF11AKR1C3AKR1C2YAP1TEAD4 | |
| SCHEMBL28119235 | 0.82 | KIF11 (0.48) | KIF11MEN1MAPTKMT2AAKR1C3 | |
| SCHEMBL28118830 | 0.81 | KIF11 (0.47) | KIF11MEN1MAPTKMT2AAKR1C3 | |
| SCHEMBL28119211 | 0.81 | IDO1 (0.47) | ATM | |
| SCHEMBL15426102 | 0.71 | TP53 (0.67) | ATMMEN1MAPTKMT2A | |
| SCHEMBL17166881 | 0.71 | ATM (0.55) | ATMMAPTHTT | |
| SCHEMBL12165522 | 0.70 | ATM (0.77) | ATMMEN1MAPTKMT2AHTT | |
| SCHEMBL7347670 | 0.69 | IDH2 (0.77) | KIF11MEN1MAPTKMT2AAKR1C3 | |
| SCHEMBL30575363 | 0.69 | IDH2 (0.77) | KIF11MEN1MAPTKMT2AAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | claimed |
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | disclosed |