Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CBX7 | O95931 | 2/20 | 0.43 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.43 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.43 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28118833 | 0.88 | ATM (0.47) | IDO1ATMPGRGSK3BNQO2 | |
| SCHEMBL2495439 | 0.86 | IDO1 (0.62) | IDO1ATMPGRCBX7CDYL | |
| SCHEMBL28119199 | 0.81 | KIF11 (0.50) | ATM | |
| SCHEMBL28118836 | 0.79 | NQO2 (0.47) | IDO1PGRGSK3BCBX7CDYL | |
| SCHEMBL28837811 | 0.79 | NQO2 (0.47) | IDO1PGRGSK3BCBX7CDYL | |
| SCHEMBL28118909 | 0.78 | NQO2 (0.46) | IDO1GSK3BCBX7CDYLCDYL2 | |
| SCHEMBL15426102 | 0.76 | TP53 (0.67) | ATMPGRTP53SMN1; SMN2PIK3CD | |
| SCHEMBL17166881 | 0.76 | ATM (0.55) | IDO1ATMPGRGSK3BTP53 | |
| SCHEMBL12165522 | 0.74 | ATM (0.77) | IDO1ATMSMN1; SMN2 | |
| SCHEMBL7465954 | 0.70 | PGR (0.52) | IDO1PGRCBX7CDYLCDYL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | claimed |
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | disclosed |