Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL783065 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1BCHEPTGS2ALOX15 | |
| SCHEMBL31512160 | 0.85 | LMNA (0.41) | MAPK1KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL783401 | 0.84 | BRD4 (0.49) | MAPK1KDM4EALDH1A1BCHEPTGS2 | |
| SCHEMBL10706603 | 0.81 | POLB (0.47) | ALDH1A1PTGS2ALOX15KMT2AMAPT | |
| SCHEMBL18334538 | 0.77 | BCHE (0.51) | KDM4EALDH1A1BCHEPTGS2ALOX15 | |
| SCHEMBL198262 | 0.76 | MAPT (0.57) | MAPK1KDM4EALDH1A1MAPTTSHR | |
| SCHEMBL11000921 | 0.74 | ALOX15 (0.49) | MAPK1KDM4EALDH1A1BCHEPTGS2 | |
| SCHEMBL17144775 | 0.74 | KDM4E (0.38) | MAPK1KDM4EALDH1A1PARP1PARP2 | |
| SCHEMBL1397134 | 0.70 | GAA (0.41) | ALDH1A1ALOX15KMT2AAPEX1MAPT | |
| SCHEMBL29288016 | 0.70 | PGR (0.46) | MAPK1KDM4EALDH1A1PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103565653-B | Substituted pyrazolone compound as well as using method and application of pyrazolone compound | 广东东阳光药业有限公司 | 2017-01-25 | — | — | CN | disclosed |