Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.36 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.36 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | SCN1A | P35498 | 3/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17320926 | 0.80 | TDP1 (0.49) | POLBAPEX1HTTTDP1TSHR | |
| SCHEMBL3101729 | 0.78 | TDP1 (0.47) | POLBAPEX1HTTTDP1TSHR | |
| SCHEMBL1325115 | 0.75 | TSHR (0.45) | POLBAPEX1HTTTDP1TSHR | |
| SCHEMBL15404816 | 0.75 | TDP1 (0.45) | POLBAPEX1HTTTDP1TSHR | |
| SCHEMBL7872447 | 0.74 | TDP1 (0.44) | POLBAPEX1HTTTDP1TSHR | |
| SCHEMBL28552216 | 0.74 | POLB (0.44) | POLBAPEX1HTTTDP1TSHR | |
| Hydrochloric Acid SCHEMBL28021051 | 0.73 | MEN1 (0.40) | HTTCHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL24312367 | 0.73 | TDP1 (0.48) | POLBAPEX1HTTTDP1TSHR | |
| SCHEMBL28173347 | 0.73 | TDP1 (0.51) | POLBAPEX1HTTTDP1TSHR | |
| Hydrochloric Acid SCHEMBL7024126 | 0.73 | CHRM1 (0.44) | POLBAPEX1HTTTDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105199530-B | Super-hydrophilic polyacrylamide coating and preparation method thereof | 中国科学院理化技术研究所 | 2017-06-06 | — | — | CN | claimed |